Clarifications! (and eyeballs...)

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So in my last blog post I received a couple comments asking me to elaborate on some of the things I mentioned.  Hopefully this entry will help lift the fog of befuddlement from your mind.

Glaucoma is a condition of the eye in which the optic nerve is damaged.  This can lead to loss of vision if not properly treated.  In most cases, abnormal intraoccular pressure causes the damage to the nerve. 

A trabeculectomy is a surgery which aleviates the pressure on the eye by permitting increased drainage of the aqueous humor.  This is done by removing a portion of the eye and allowing more liquid to flow out of the eye.

A tube surgery may be done to bypass that area of the eye completely and allow an increased amount of fluid to drain by inserting a tube into the eye.

Both of these surgeries achieve the same thing through different means.

If there is still any confusion then let me know!

 

Now for some normal blogging.

Since my last blog post I have been doing much of the same thing, going through patient files and entering data into the database I created.  On Friday, however, I worked with Dr. Chris Shen.  He has been working on a research project which Dr. Mansberger assigned to him.  He is attempting to discover a way to measure the pressure on eyes which have a fake lens inserted.  Pressure is usually taken on the cornea, but once patients have received this lens implant it is inaccurate to take pressure from the cornea.  We were working with donor eyeballs and using them to measure the pressure on the cornea, the limbus (where the cornea meets the sclera, the edge of the iris), and a constant point on the sclera.  We hooked up a bottle of fluid to an IV line and ran it through tubing to a machine which measured pressure.  After the tubing went through the machine it was inserted into one of the eyeballs with a needle.  The pressure of the eye was increased and decreased by raising and lowering the IV.  We measured at four different pressures (10, 20, 30, and 40) and used two different instruments.  We used a Tono-Pen, which you use by tapping against the eye.  It takes all of the different readings from the taps and produces an average and a percent error.  We also used a Schiotz tonometer.  The Schiotz physically rests on top of the eye and uses weights to produce a reading for the pressure.  It was more frequently used in the 50s but if it proves accurate it may make a comeback.  After we finished one eye, Dr. Michael Straiko came and replaced the lens with an implant lens.  As we worked on the second eye he worked on the first.  My job was to adjust the IV and write down the pressures as Dr. Shen told them to me.  I was not allowed to tell Dr. Shen the pressures of each test or else he might have biased himself and chose readings which were closer to the actual pressure.  This experience was very interesting, I hope I get to work with Dr. Shen again.

Comments

normail blogging

Today you're at the zoo, around animals and children with normal eye pressure (or at least one hopes this is true.)
How have you spent the last coupe of days? Any more tonometers? Computer screens? Making data blind around not-blind patients who could become blind?
Are patient files and databases interesting enough? Does it seem like secretarial work or does it feel scientific to you? I must depend on whether you are reading any statistical analysis of the data entry... Or maybe you're just thinking deeply. Or chatting with your mentor.

Tell us all.

clarification over clarification

Matthew.... I'd like you to define how glaucoma is the condition in which eye pressure is high... which can lead to damage of the optic nerve, which can lead to blindness. Could you explain the pathopysiology of this? Maybe a crash course on the anatomy of the aqueous humor and the Canal of Schlemm is in order.
This would clarify why measuring eye ball pressure is so essential and why a tonometer is "the tool" in this condition.
And can you define what you mean by "tube surgery"... A valve? Ahmed valves? or the simple placement of a tube for drainage?
And when you discuss a "fake lens", are you talking about the intraocular lens (as the one replaced during cataract surgery) or lenses used to change the shapes of the cornea?

Also, it may be relevant to discuss how a double blind study is much more valid than a single blind (or no blindness) study.

I know, I know, this is science heavy... But how will the readers understand? You can do this in a couple of minutes, yes?
It sounds like your time is has been spent in good ways. Are you enjoying the database work?